block F5 = Refresh when debugging.

ILSpy/MainWindow.xaml.cs

@@ -297,11 +297,13 @@ namespace ICSharpCode.ILSpy
 		
 		void RefreshCommandExecuted(object sender, ExecutedRoutedEventArgs e)
 		{
+			if (!DebuggerService.CurrentDebugger.IsDebugging) {
 				e.Handled = true;
 				var path = GetPathForNode(treeView.SelectedItem as SharpTreeNode);
 				ShowAssemblyList(assemblyListManager.LoadList(ILSpySettings.Load(), assemblyList.ListName));
 				SelectNode(FindNodeByPath(path, true));
 			}
+		}
 		
 		void AttachToProcessExecuted(object sender, ExecutedRoutedEventArgs e)
 		{