diff --git a/src/Main/Base/Project/Src/Project/Behaviors/DotNetStartBehavior.cs b/src/Main/Base/Project/Src/Project/Behaviors/DotNetStartBehavior.cs
index 148b8d5b4d..a90a60d10d 100644
--- a/src/Main/Base/Project/Src/Project/Behaviors/DotNetStartBehavior.cs
+++ b/src/Main/Base/Project/Src/Project/Behaviors/DotNetStartBehavior.cs
@@ -114,7 +114,7 @@ namespace ICSharpCode.SharpDevelop.Project
 			if (fx != null)
 				UpdateAppConfig(fx);
 			if (Project.OutputType != OutputType.Library) {
-				if (DotnetDetection.IsDotnet45Installed()) {
+				if (DotnetDetection.IsDotnet45Installed() && fx.IsBasedOn(TargetFramework.Net45)) {
 					Project.SetProperty(null, Project.ActivePlatform, "Prefer32Bit", "True", PropertyStorageLocations.PlatformSpecific, true);
 				} else {
 					Project.SetProperty(null, Project.ActivePlatform, "PlatformTarget", "x86", PropertyStorageLocations.PlatformSpecific, true);