diff --git a/ICSharpCode.Decompiler/CSharp/CallBuilder.cs b/ICSharpCode.Decompiler/CSharp/CallBuilder.cs
index 3ceeeaf60..39cdba538 100644
--- a/ICSharpCode.Decompiler/CSharp/CallBuilder.cs
+++ b/ICSharpCode.Decompiler/CSharp/CallBuilder.cs
@@ -373,6 +373,20 @@ namespace ICSharpCode.Decompiler.CSharp
 				return HandleImplicitConversion(method, argumentList.Arguments[0]);
 			}
 
+			if (settings.LiftNullables && method.Name == "GetValueOrDefault"
+				&& method.DeclaringType.IsKnownType(KnownTypeCode.NullableOfT)
+				&& method.DeclaringType.TypeArguments[0].IsKnownType(KnownTypeCode.Boolean)
+				&& argumentList.Length == 0)
+			{
+				argumentList.CheckNoNamedOrOptionalArguments();
+				return new BinaryOperatorExpression(
+					target.Expression,
+					BinaryOperatorType.Equality,
+					new PrimitiveExpression(true))
+					.WithRR(new CSharpInvocationResolveResult(target.ResolveResult, method,
+						argumentList.GetArgumentResolveResults(), isExpandedForm: argumentList.IsExpandedForm));
+			}
+
 			var transform = GetRequiredTransformationsForCall(expectedTargetDetails, method, ref target,
 				ref argumentList, CallTransformation.All, out IParameterizedMember foundMethod);
 
diff --git a/ICSharpCode.Decompiler/CSharp/Transforms/PatternStatementTransform.cs b/ICSharpCode.Decompiler/CSharp/Transforms/PatternStatementTransform.cs
index f9a605012..3605d968d 100644
--- a/ICSharpCode.Decompiler/CSharp/Transforms/PatternStatementTransform.cs
+++ b/ICSharpCode.Decompiler/CSharp/Transforms/PatternStatementTransform.cs
@@ -1167,6 +1167,17 @@ namespace ICSharpCode.Decompiler.CSharp.Transforms
 			}
 			return base.VisitBinaryOperatorExpression(expr);
 		}
+
+		public override AstNode VisitUnaryOperatorExpression(UnaryOperatorExpression expr)
+		{
+			if (expr.Operator == UnaryOperatorType.Not && expr.Expression is BinaryOperatorExpression { Operator: BinaryOperatorType.Equality } binary)
+			{
+				binary.Operator = BinaryOperatorType.InEquality;
+				expr.ReplaceWith(binary.Detach());
+				return VisitBinaryOperatorExpression(binary);
+			}
+			return base.VisitUnaryOperatorExpression(expr);
+		}
 		#endregion
 
 		#region C# 7.3 pattern based fixed (for value types)
diff --git a/ICSharpCode.Decompiler/IL/Transforms/ExpressionTransforms.cs b/ICSharpCode.Decompiler/IL/Transforms/ExpressionTransforms.cs
index 5385bbaae..b9b99ad42 100644
--- a/ICSharpCode.Decompiler/IL/Transforms/ExpressionTransforms.cs
+++ b/ICSharpCode.Decompiler/IL/Transforms/ExpressionTransforms.cs
@@ -96,8 +96,7 @@ namespace ICSharpCode.Decompiler.IL.Transforms
 				return;
 			}
 			else if (inst.Kind == ComparisonKind.Inequality && inst.LiftingKind == ComparisonLiftingKind.None
-			  && inst.Right.MatchLdcI4(0) && (IfInstruction.IsInConditionSlot(inst) || inst.Left is Comp)
-		  )
+				&& inst.Right.MatchLdcI4(0) && (IfInstruction.IsInConditionSlot(inst) || inst.Left is Comp))
 			{
 				// if (comp(x != 0)) ==> if (x)
 				// comp(comp(...) != 0) => comp(...)
@@ -107,6 +106,7 @@ namespace ICSharpCode.Decompiler.IL.Transforms
 				inst.Left.AcceptVisitor(this);
 				return;
 			}
+			new NullableLiftingTransform(context).Run(inst);
 
 			base.VisitComp(inst);
 			if (inst.IsLifted)
diff --git a/ICSharpCode.Decompiler/IL/Transforms/NullableLiftingTransform.cs b/ICSharpCode.Decompiler/IL/Transforms/NullableLiftingTransform.cs
index 4e297b00d..3d517e463 100644
--- a/ICSharpCode.Decompiler/IL/Transforms/NullableLiftingTransform.cs
+++ b/ICSharpCode.Decompiler/IL/Transforms/NullableLiftingTransform.cs
@@ -85,6 +85,33 @@ namespace ICSharpCode.Decompiler.IL.Transforms
 			return false;
 		}
 
+		/// <summary>
+		/// VS2022.10 / Roslyn 4.10.0 adds an optimization that turns
+		/// a == 42 into a.GetValueOrDefault() == 42 without any HasValue check.
+		/// </summary>
+		public void Run(Comp comp)
+		{
+			if (!comp.IsLifted && comp.Kind.IsEqualityOrInequality())
+			{
+				var left = comp.Left;
+				var right = comp.Right;
+				if (MatchGetValueOrDefault(left, out ILInstruction arg)
+					&& right.MatchLdcI(out var value) && value != 0)
+				{
+					context.Step("comp(a.GetValueOrDefault() == const) -> comp.lifted(a == const)", comp);
+					comp.LiftingKind = ComparisonLiftingKind.CSharp;
+					comp.Left = new LdObj(arg, ((Call)left).Method.DeclaringType);
+				}
+				else if (MatchGetValueOrDefault(right, out arg)
+					&& left.MatchLdcI(out value) && value != 0)
+				{
+					context.Step("comp(const == a.GetValueOrDefault()) -> comp.lifted(const == a)", comp);
+					comp.LiftingKind = ComparisonLiftingKind.CSharp;
+					comp.Right = new LdObj(arg, ((Call)right).Method.DeclaringType);
+				}
+			}
+		}
+
 		public bool RunStatements(Block block, int pos)
 		{
 			// e.g.: