diff --git a/ICSharpCode.Decompiler.Tests/TestCases/ILPretty/Unsafe.cs b/ICSharpCode.Decompiler.Tests/TestCases/ILPretty/Unsafe.cs
index 4ba4af434..8095453ef 100644
--- a/ICSharpCode.Decompiler.Tests/TestCases/ILPretty/Unsafe.cs
+++ b/ICSharpCode.Decompiler.Tests/TestCases/ILPretty/Unsafe.cs
@@ -150,7 +150,7 @@ namespace System.Runtime.CompilerServices
 		[MethodImpl(MethodImplOptions.AggressiveInlining)]
 		public unsafe static T Read<T>(void* source)
 		{
-			return *(T*)source;
+			return Unsafe.Read<T>(source);
 		}
 
 		[MethodImpl(MethodImplOptions.AggressiveInlining)]
@@ -168,7 +168,7 @@ namespace System.Runtime.CompilerServices
 		[MethodImpl(MethodImplOptions.AggressiveInlining)]
 		public unsafe static void Write<T>(void* destination, T value)
 		{
-			*(T*)destination = value;
+			Unsafe.Write(destination, value);
 		}
 
 		[MethodImpl(MethodImplOptions.AggressiveInlining)]
@@ -186,13 +186,13 @@ namespace System.Runtime.CompilerServices
 		[MethodImpl(MethodImplOptions.AggressiveInlining)]
 		public unsafe static void Copy<T>(void* destination, ref T source)
 		{
-			*(T*)destination = source;
+			Unsafe.Write(destination, source);
 		}
 
 		[MethodImpl(MethodImplOptions.AggressiveInlining)]
 		public unsafe static void Copy<T>(ref T destination, void* source)
 		{
-			destination = *(T*)source;
+			destination = Unsafe.Read<T>(source);
 		}
 
 		[MethodImpl(MethodImplOptions.AggressiveInlining)]
diff --git a/ICSharpCode.Decompiler/CSharp/ExpressionBuilder.cs b/ICSharpCode.Decompiler/CSharp/ExpressionBuilder.cs
index b03f38b4a..70d39da45 100644
--- a/ICSharpCode.Decompiler/CSharp/ExpressionBuilder.cs
+++ b/ICSharpCode.Decompiler/CSharp/ExpressionBuilder.cs
@@ -2797,6 +2797,17 @@ namespace ICSharpCode.Decompiler.CSharp
 				{
 					target = target.ConvertTo(new ByReferenceType(loadType), this);
 				}
+				else if (!loadType.IsUnmanagedType(settings.IntroduceUnmanagedConstraint))
+				{
+					// Use: Unsafe.Read<T>(void*)
+					target = target.ConvertTo(new PointerType(compilation.FindType(KnownTypeCode.Void)), this, allowImplicitConversion: true);
+					return CallUnsafeIntrinsic(
+						name: "Read",
+						arguments: new Expression[] { target },
+						returnType: loadType,
+						typeArguments: new IType[] { loadType }
+					);
+				}
 				else
 				{
 					target = target.ConvertTo(new PointerType(loadType), this);
@@ -2815,9 +2826,9 @@ namespace ICSharpCode.Decompiler.CSharp
 
 		protected internal override TranslatedExpression VisitStObj(StObj inst, TranslationContext context)
 		{
-			if (inst.UnalignedPrefix != 0)
+			if (inst.UnalignedPrefix != 0 || (inst.Target.ResultType != StackType.Ref && !inst.Type.IsUnmanagedType(settings.IntroduceUnmanagedConstraint)))
 			{
-				return UnalignedStObj(inst);
+				return StObjViaHelperCall(inst);
 			}
 
 			IType pointerTypeHint = inst.Target.ResultType == StackType.Ref ? new ByReferenceType(inst.Type) : (IType)new PointerType(inst.Type);
@@ -2892,14 +2903,16 @@ namespace ICSharpCode.Decompiler.CSharp
 			}
 		}
 
-		private TranslatedExpression UnalignedStObj(StObj inst)
+		private TranslatedExpression StObjViaHelperCall(StObj inst)
 		{
 			// "unaligned.1; stobj" -> decompile to a call of
 			//    Unsafe.WriteUnaligned<T>(void*, T)
 			// or Unsafe.WriteUnaligned<T>(ref byte, T)
+			// "stobj ManagedType" -> decompile to a call of
+			//    Unsafe.Write<T>(void*, T)
 			var pointer = Translate(inst.Target);
 			var value = Translate(inst.Value, typeHint: inst.Type);
-			if (pointer.Expression is DirectionExpression)
+			if (pointer.Expression is DirectionExpression && inst.UnalignedPrefix != 0)
 			{
 				pointer = pointer.ConvertTo(new ByReferenceType(compilation.FindType(KnownTypeCode.Byte)), this);
 			}
@@ -2911,12 +2924,24 @@ namespace ICSharpCode.Decompiler.CSharp
 			{
 				value = value.ConvertTo(inst.Type, this);
 			}
-			return CallUnsafeIntrinsic(
-				name: "WriteUnaligned",
-				arguments: new Expression[] { pointer, value },
-				returnType: compilation.FindType(KnownTypeCode.Void),
-				inst: inst
-			);
+			if (inst.UnalignedPrefix != 0)
+			{
+				return CallUnsafeIntrinsic(
+					name: "WriteUnaligned",
+					arguments: new Expression[] { pointer, value },
+					returnType: compilation.FindType(KnownTypeCode.Void),
+					inst: inst
+				);
+			}
+			else
+			{
+				return CallUnsafeIntrinsic(
+					name: "Write",
+					arguments: new Expression[] { pointer, value },
+					returnType: inst.Type,
+					inst: inst
+				);
+			}
 		}
 
 		protected internal override TranslatedExpression VisitLdLen(LdLen inst, TranslationContext context)